Abstract

Gene delivery systems necessitate the gene therapy, which is a unique approach for applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral vectors like high cost, poor target cell specificity, and inability in transferring the large size genes, the non-viral vectors/carriers have been introduced for achieving better efficacy in gene therapy. A variety of carriers including liposomes, metallic/polymeric nanoparticles, dendrimers, gelatins, quantum dots/rods, etc. has been depicted distinct features in the gene therapy. Herein, the advances and applications of natural/synthetic polymeric carriers have been summarized in gene therapy and disadvantages/challenges have been also discussed.

摘要

基因传递系统需要基因治疗，这是一种应用可调基因治疗任何疾病的独特方法。为了解决病毒载体成本高、靶细胞特异性差、无法转移大尺寸基因等缺点，引入非病毒载体/载体以实现更好的基因治疗效果。包括脂质体、金属/聚合物纳米粒子、树枝状聚合物、明胶、量子点/棒等在内的各种载体在基因治疗中都具有明显的特征。本文综述了天然/合成聚合物载体在基因治疗中的进展和应用，并讨论了其缺点/挑战。