Cell Cycle ( IF 4.3 ) Pub Date : 2020-10-04 , DOI: 10.1080/15384101.2020.1824448 Jianan Zheng 1 , Hui Yu 1, 2 , Anqi Zhou 1 , Bingfeng Wu 1 , Jiayi Liu 1 , Yinan Jia 1 , Lin Xiang 1, 2
ABSTRACT
Hippo pathway is a chain of kinases consists of a series of protein kinases and transcription factors. Meanwhile, oxidative stress is a condition of elevated concentrations of reactive oxygen species (ROS) that cause molecular damage to vital structures and functions. Both of them are key regulators in cell proliferation, survival, and development. These processes are strictly regulated by highly coordinated mechanisms, including c-Jun n-terminal kinase (JNK) pathway, mTOR pathway and a number of extrinsic and intrinsic factors. Recently, emerging evidence suggests that Hippo pathway is involved in the responses to cellular stresses, including mechanic stress, DNA damage, and oxidative stress, to mediate biological process, such as apoptosis, pyroptosis, and metastasis. But the exact mechanism remains to be further explored. Therefore, the purpose of this review is to summarize recent findings and discuss how Hippo pathway, oxidative stress, and the crosstalk between them regulate some biological process which determines cell fate.
中文翻译:
探戈需要两个:Hippo通路与生物过程中氧化还原信号的耦合
摘要
Hippo 通路是由一系列蛋白激酶和转录因子组成的激酶链。同时,氧化应激是活性氧 (ROS) 浓度升高的一种情况,可对重要结构和功能造成分子损伤。它们都是细胞增殖、存活和发育的关键调节剂。这些过程受到高度协调的机制的严格调控,包括 c-Jun 正端激酶 (JNK) 通路、mTOR 通路和许多外在和内在因素。最近,新出现的证据表明 Hippo 通路参与对细胞应激的反应,包括机械应激、DNA 损伤和氧化应激,以介导生物过程,如细胞凋亡、细胞焦亡和转移。但确切的机制还有待进一步探索。所以,