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A new cytotoxic indole alkaloid from the fungus Penicillium polonicum TY12
Natural Product Research ( IF 2.2 ) Pub Date : 2020-10-04 , DOI: 10.1080/14786419.2020.1828406
Xue-Yun Cai 1 , Jia-Peng Wang 1 , Yan Shu 1 , Jun-Tao Hu 1 , Cheng-Tong Sun 1 , Le Cai 1 , Zhong-Tao Ding 1
Affiliation  

Abstract

A new dimeric monoterpene indole alkaloid polonidine A (1), along with five known compounds, cyclopenol (2), verrucosidin (3), fructigenine A (4), 3-O-methylviridicatin (5) and aurantiomides C (6), were isolated from Penicillium polonicum TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 exhibited moderate cytotoxic activities and moderate antibacterial activity against Bacillus subtilis with MIC of 4.0 μg/mL.



中文翻译:

来自真菌Penicillium polonicum TY12的一种新的细胞毒性吲哚生物碱

摘要

一种新的二聚体单萜吲哚生物碱波乐定 A ( 1 ),以及五种已知化合物,环戊醇 ( 2 )、verrucosidin ( 3 )、果糖甙碱 A ( 4 )、3-O-methylviridicatin ( 5 ) 和 aurantiomides C ( 6 ),从 polonicum TY12中分离得到。它们的结构是在广泛的光谱分析的基础上建立的。化合物1对枯草芽孢杆菌表现出中等的细胞毒活性和中等的抗菌活性,MIC为4.0 μg/mL。

更新日期:2020-10-04
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