ABSTRACT

Objectives

This meta-analysis was performed to investigate the associations between single-nucleotide polymorphisms (SNPs) in the TGF- β and Smad3 genes and arthritis.

Methods

A meta-analysis was performed in STATA 14.0, with publication bias and meta-regression analysis. All types of arthritis were included, and subgroup analyses were performed to interpret variations among different types of arthritis.

Results

Twenty-two qualified studieswere selected to analyze the pooled accuracy, and 4 SNP sites were involved. The analysis of the TGFB1 SNP rs1800470 showed an association with arthritis in allelic (P = 0.011), homozygous (P = 0.034) and recessive (P = 0.021) genetic models. The analysis of the TGFB1 SNP rs1800471 demonstrated a close association with rheumatoid arthritis (RA) in homozygous (P = 0.000, 95%) and recessive (P = 0.008) models. The analysis of the SMAD3 SNP rs12901499 revealed a close association with osteoarthritis (OA) in the allelic (P = 0.001) model.

Conclusion

This research showed that genetic variants of the TGF-β pathway impact arthritis. The polymorphisms rs1800470, rs1800471 and rs12901499 were correlated with a higher prevalence of arthritis.

中文翻译：

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TGF-β和Smad3基因多态性与关节炎易感性的相关性：荟萃分析

摘要

目标

进行这项荟萃分析是为了研究 TGF-β 和 Smad3 基因中的单核苷酸多态性 (SNP) 与关节炎之间的关联。

方法

在 STATA 14.0 中进行了荟萃分析，进行了发表偏倚和荟萃回归分析。包括所有类型的关节炎，并进行亚组分析以解释不同类型关节炎之间的差异。

结果

选择了 22 项合格的研究来分析汇总的准确性，涉及 4 个 SNP 位点。TGFB1 SNP rs1800470 的分析表明在等位基因 (P = 0.011)、纯合 (P = 0.034) 和隐性 (P = 0.021) 遗传模型中与关节炎相关。TGFB1 SNP rs1800471 的分析表明，在纯合子 (P = 0.000, 95%) 和隐性 (P = 0.008) 模型中与类风湿性关节炎 (RA) 密切相关。SMAD3 SNP rs12901499 的分析揭示了等位基因 (P = 0.001) 模型中与骨关节炎 (OA) 的密切关联。

结论

这项研究表明，TGF-β 通路的遗传变异会影响关节炎。多态性 rs1800470、rs1800471 和 rs12901499 与较高的关节炎患病率相关。