Abstract

Background

Cocaine use has increased worldwide in recent years. However, the specific effects of smoking coca paste and its consequences on the cognitive functioning of individuals are unknown. The purposes of this study were to compare the neuropsychological functioning of a group of 163 individuals with coca-paste use disorder (CPUD) to that of a group of 162 healthy controls (HC) and to examine the relationship between cognitive performance and sociodemographic characteristics of these groups.

Methods

Participants were administered a comprehensive neuropsychological battery that included tests of learning and memory, language and executive functions.

Results

Although there were no significant differences in age and educational level between the groups, individuals with CPUD had significantly lower cognitive performance on the tests of learning and memory, language and executive functions compared with HC. An interaction effect was observed between group (CPUD versus HC) and educational level in the cognitive domains of learning and memory and language, such that more years of education was associated with better performance in these domains only in the HC.

Conclusions

Deficits in learning and memory, language and executive functions are common in individuals with CPUD. Cognitive rehabilitation programs have been shown to improve these functions in individuals with CPUD. Therefore, this study reinforces the necessity of including such programs as part of the holistic intervention plan for these individuals.

中文翻译：

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古柯糊使用障碍患者的神经心理功能

摘要

背景

近年来，可卡因的使用在全球范围内有所增加。然而，吸食古柯糊的具体影响及其对个体认知功能的影响尚不清楚。本研究的目的是比较一组 163 名古柯膏使用障碍 (CPUD) 患者与一组 162 名健康对照 (HC) 患者的神经心理功能，并检查认知表现与社会人口学特征之间的关系。这些群体。

方法

参与者接受了全面的神经心理学测试，包括学习和记忆、语言和执行功能的测试。

结果

尽管各组之间的年龄和教育水平没有显着差异，但与 HC 相比，CPUD 个体在学习记忆、语言和执行功能测试中的认知表现明显较低。在学习、记忆和语言的认知领域中，组（CPUD 与 HC）和教育水平之间存在交互作用，因此只有在 HC 中，受教育年限越长，这些领域的表现越好。

结论

学习和记忆、语言和执行功能的缺陷在 CPUD 患者中很常见。认知康复计划已被证明可以改善 CPUD 患者的这些功能。因此，本研究强调了将此类计划作为针对这些人的整体干预计划的一部分的必要性。