In traditional microbial biobutanol production, the solvent must be recovered during fermentation process for a sufficient space‐time yield. Thermal separation is not feasible due to the boiling point of n‐butanol. As an integrated and selective solid‐liquid separation alternative, solvent impregnated resins (SIRs) were applied. Two polymeric resins were evaluated and an extractant screening was conducted. Vacuum application with vapor collection in fixed‐bed column as bioreactor bypass was successfully implemented as butanol desorption step. In course of further increasing process economics, fermentation with renewable lignocellulosic substrates was conducted using Clostridium acetobutylicum. Utilization of SIR was shown to be a potential strategy for solvent removal from fermentation broth, while application of a bypass column allows for product removal and recovery at once.

中文翻译：

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从木质纤维素中提纯的丁醇–溶剂浸渍树脂，用于整体选择性去除

在传统的微生物生物丁醇生产中，必须在发酵过程中回收溶剂以获得足够的时空产量。由于正丁醇的沸点，热分离是不可行的。作为一种集成的，选择性的固液分离替代方案，使用了溶剂浸渍树脂（SIR）。评价了两种聚合树脂并进行了萃取剂筛选。作为丁醇脱附步骤，已成功实施了在固定床塔中进行蒸汽收集并作为生物反应器旁路的真空应用。在进一步提高工艺经济性的过程中，使用丙酮丁醇梭菌（Clostridium acetobutylicum）进行了可再生木质纤维素底物的发酵。。使用SIR被证明是从发酵液中去除溶剂的一种潜在策略，而使用旁路色谱柱则可以立即去除和回收产物。