The primary cilium is a nonmotile microtubule‐based structure, which functions as an antenna‐like cellular sensing organelle. The primary cilium is assembled from the basal body, a mother centriole‐based structure, during interphase or a quiescent cell stage, and rapidly disassembles before entering mitosis in a dynamic cycle. Defects in this ciliogenesis dynamics are associated with human diseases such as ciliopathy and cancer, but the molecular mechanisms of the ciliogenesis dynamics are still largely unknown. To date, various cellular signaling pathways associated with primary cilia have been proposed, but the main signaling pathways regulating primary cilia assembly/disassembly remain enigmatic. This review describes recent findings in Wnt‐induced primary cilia assembly/disassembly and potential future directions for the study of the cellular signaling related to the primary ciliogenesis dynamics.

中文翻译：

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Wnt信号参与原发性纤毛的组装和拆卸

初级纤毛是基于非运动微管的结构，其功能类似于天线的细胞传感细胞器。初级纤毛在相间或静止细胞阶段从基体（基于母体的母体结构）组装而成，并在动态循环进入有丝分裂之前迅速分解。这种纤毛发生动力学的缺陷与人类疾病如纤毛病和癌症有关，但是纤毛发生动力学的分子机制仍然是未知的。迄今为止，已经提出了与原发纤毛相关的各种细胞信号传导途径，但是调节原发纤毛组装/拆卸的主要信号传导途径仍然是谜。