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Benefits of time‐resolved nonuniform sampling in reaction monitoring: The case of aza‐Michael addition of benzylamine and acrylamide
Magnetic Resonance in Chemistry ( IF 2 ) Pub Date : 2020-10-15 , DOI: 10.1002/mrc.5105
Dariusz Gołowicz 1, 2 , Magdalena Kaźmierczak 1, 3 , Krzysztof Kazimierczuk 1
Affiliation  

Monitoring of chemical reactions is best carried out using methods that sample the test object at a rate greater than the time scale of the processes taking place. The recently proposed time-resolved non-uniform sampling (TR-NUS) method allows the use of two-dimensional (2D) NMR spectra for this purpose, and provides a time resolution equivalent to that achievable using one-dimensional spectra. Herein we show that TR-NUS acquired data eliminates 2D spectral line disturbances and enables more accurate signal integration and kinetics conclusions. The considerations are exemplified with a seemingly simple aza-Michael reaction of benzylamine and acrylamide. Surprisingly, the product identification is possible only using 2D spectra, while credible monitoring requires TR-NUS.

中文翻译:

时间分辨非均匀采样在反应监测中的优势:苄胺和丙烯酰胺的 aza-Michael 加成案例

化学反应的监测最好使用以大于发生过程的时间尺度的速率对测试对象进行采样的方法。最近提出的时间分辨非均匀采样 (TR-NUS) 方法允许为此使用二维 (2D) NMR 光谱,并提供与使用一维光谱可实现的等效的时间分辨率。在这里,我们展示了 TR-NUS 采集的数据消除了 2D 谱线干扰,并使信号整合和动力学结论更加准确。这些考虑以看似简单的苄胺和丙烯酰胺的氮杂-迈克尔反应为例。令人惊讶的是,产品识别只能使用 2D 光谱,而可靠的监测需要 TR-NUS。
更新日期:2020-10-15
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