Polycyclic aromatic hydrocarbons (PAHs) and ultraviolet radiation (UV) represent genotoxic factors that commonly occur in the living and working environment. The dermal form of exposure represents a significant part of the total load of dangerous chemical and physical environmental factors to which an organism is subjected. However, simultaneous dermal exposures to PAHs (pharmaceutical crude coal tar [CCT]) and UV (UVA and UVB) also have therapeutic uses. A typical example is Goeckerman therapy (GT) for psoriasis. The question of the therapeutic efficacy of GT and the related level of genotoxic danger is still under discussion. The aim of the present study was to compare four GT variants (G1–G4) in terms of efficacy and acceptable genotoxic hazard. Efficacy was expressed by the psoriasis area of severity index (PASI) score, genotoxic hazard by chromosomal aberration in peripheral lymphocytes. The lowest risk of genotoxic hazard and the lowest efficiency was observed in G1 variant (3% of the CCT and UVA + UVB). The efficacy of G2 (4% CCT and UVA + UVB), G3 (4% CCT and UVB), and G4 variants (5% CCT and UVA + UVB) was comparable. The highest risk of genotoxic hazard was found in the G3 variant. In the terms of sufficient efficacy and acceptable genotoxic hazard, a combination of 4% or 5% of CCT and UVA and UVB seems to be acceptable (variants G2 and G4).

中文翻译：

---

同时治疗性暴露于多环芳烃和紫外线辐射的遗传毒性作用

多环芳烃 (PAH) 和紫外线辐射 (UV) 是生活和工作环境中常见的遗传毒性因素。皮肤接触形式代表了生物体受到的危险化学和物理环境因素总负荷的重要部分。然而，同时皮肤接触多环芳烃（药物粗煤焦油 [CCT]）和紫外线（UVA 和 UVB）也有治疗用途。一个典型的例子是银屑病的 Goeckerman 疗法 (GT)。GT 的治疗效果和相关的遗传毒性危险程度的问题仍在讨论中。本研究的目的是在功效和可接受的遗传毒性风险方面比较四种 GT 变体（G1-G4）。疗效由银屑病严重程度指数（PASI）评分表示，外周淋巴细胞染色体畸变的遗传毒性危害。在 G1 变体（CCT 的 3% 和 UVA + UVB）中观察到最低的遗传毒性危害风险和最低的效率。G2（4% CCT 和 UVA + UVB）、G3（4% CCT 和 UVB）和 G4 变体（5% CCT 和 UVA + UVB）的功效相当。在 G3 变体中发现了最高的遗传毒性危害风险。就足够的功效和可接受的遗传毒性危害而言，4% 或 5% 的 CCT 与 UVA 和 UVB 的组合似乎是可以接受的（变体 G2 和 G4）。在 G3 变体中发现了最高的遗传毒性危害风险。就足够的功效和可接受的遗传毒性危害而言，4% 或 5% 的 CCT 与 UVA 和 UVB 的组合似乎是可以接受的（变体 G2 和 G4）。在 G3 变体中发现了最高的遗传毒性危害风险。就足够的功效和可接受的遗传毒性危害而言，4% 或 5% 的 CCT 与 UVA 和 UVB 的组合似乎是可以接受的（变体 G2 和 G4）。