Bipolar disorder (BD) is characterized by severe mood symptoms, often accompanied by circadian rhythm disturbances. Preclinical studies indicate that lithium, a first line treatment for BD, has effects on circadian rhythms. ¹ However, less attention has been given to the effects of lithium on the clinical symptoms of BD related to circadian rhythm disruption. We present a case of a BD patient with profound disruption in sleep/wake activity and show that lithium potently corrected her circadian rhythm disturbances.

中文翻译：

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在具有家族性 BRCA1 突变的双相情感障碍病例中，锂可纠正睡眠和昼夜节律紊乱

双相情感障碍 (BD) 的特征是严重的情绪症状，通常伴有昼夜节律紊乱。临床前研究表明，锂是 BD 的一线治疗药物，对昼夜节律有影响。¹然而，锂对与昼夜节律紊乱相关的 BD 临床症状的影响却很少受到关注。我们介绍了一名 BD 患者的睡眠/清醒活动严重中断的案例，并表明锂有效地纠正了她的昼夜节律紊乱。