It is very desirable to develop advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications. Herein, biomass‐derived multilayer‐structured absorbable microparticles (MQ_xT_y) composed of starches and plant polyphenols are readily constructed for the safe and effective treatment of bone defects with intractable bleeding by coating multiple layers of quaternized starch (Q⁺) and tannic acid onto microporous starch microparticles via facile layer‐by‐layer assembly. MQ_xT_y microparticles exhibit efficient degradability, low cytotoxicity, and good blood compatibility. Among various MQ_xT_y microparticles with distinct Q⁺/T⁻ double layers, MQ₂T₂ with outmost polyphenol layer possess the unique properties of platelet adhesion/activation and red blood cell aggregation, resulting in the best hemostatic performance. In a mouse cancellous‐bone‐defect model, MQ₂T₂ exhibits the favorable hemostatic effect, low inflammation/immune responses, high biodegradability, and promoted bone repair. A proof‐of‐concept study of beagles further confirms the good performance of MQ₂T₂ in controlling intractable bleeding of bone defects. The present work demonstrates that such biomass‐based multilayer‐structured microparticles are very promising biomedical materials for clinical use.

中文翻译：

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用于加速止血和骨修复的生物质衍生的多层结构微粒

非常需要开发具有优异生物安全性和生物活性的先进可持续生物医学材料用于临床应用。本文中，由淀粉和植物多酚组成的生物质衍生的多层结构可吸收微粒（MQ _x T _y）很容易构建，通过涂覆多层季铵化淀粉（Q ⁺）和单宁，可以安全有效地治疗顽固性出血的骨缺损通过简单的逐层组装将酸附着到微孔淀粉微粒上。MQ _x T _y微粒具有高效降解性、低细胞毒性和良好的血液相容性。在各种具有明显Q ⁺ /T ^-双层的MQ _x T _{y微粒中，最外层为多酚层的MQ 2} T ₂具有血小板粘附/活化和红细胞聚集的独特性质，从而具有最佳的止血性能。在小鼠松质骨缺损模型中，MQ ₂ T ₂表现出良好的止血作用、低炎症/免疫反应、高生物降解性并促进骨修复。对比格犬的概念验证研究进一步证实了 MQ ₂ T ₂在控制骨缺损顽固性出血方面的良好性能。目前的工作表明，这种基于生物质的多层结构微粒是非常有前途的临床生物医学材料。