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Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy
Advanced Materials ( IF 29.4 ) Pub Date : 2020-10-05 , DOI: 10.1002/adma.202002085
Shuang Qing 1, 2 , Chengliang Lyu 1 , Li Zhu 3 , Chao Pan 3 , Shuang Wang 1 , Feng Li 1, 2 , Jianghua Wang 1, 2 , Hua Yue 1 , Xiaoyong Gao 1 , Rongrong Jia 4 , Wei Wei 1, 2 , Guanghui Ma 1, 2
Affiliation  

The highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming. To overcome the obstacles of antibody‐dependent clearance and high toxicity induced by OMVs upon intravenous injection (a classic clinically relevant delivery mode), calcium phosphate (CaP) shells are employed to cover the surface of OMVs, which enables potent OMV‐based TME reprograming without side effects. Meanwhile, the pH‐sensitive CaP shells facilitate the neutralization of acidic TME, leading to highly beneficial M2‐to‐M1 polarization of macrophages for improved antitumor effect. Moreover, the outer shells can be integrated with functional components like folic acid or photosensitizer agents, which facilitates the use of the OMV‐based platform in combination therapies for a synergic therapeutic effect.

中文翻译:

生物矿化细菌外膜囊泡增强安全有效的肿瘤微环境重编程用于抗癌治疗

实体瘤中高度免疫抑制的肿瘤微环境 (TME) 通常会抑制免疫治疗的疗效。在这项研究中,细菌外膜囊泡 (OMV) 被证明是 TME 重编程的强大免疫刺激剂。为了克服静脉注射 OMV 诱导的抗体依赖性清除和高毒性障碍(一种经典的临床相关递送模式),采用磷酸钙 (CaP) 壳覆盖 OMV 表面,从而实现有效的基于 OMV 的 TME 重编程没有副作用。同时,pH敏感的CaP壳促进酸性TME的中和,导致巨噬细胞的M2-to-M1极化非常有益,以提高抗肿瘤效果。此外,外壳可以与叶酸或光敏剂等功能成分结合在一起,
更新日期:2020-11-25
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