The transfer of cryopreserved blastocysts is increasing in IVF centres. However, little is known about the perinatal and obstetric outcomes of this procedure. In an attempt to further elucidate these issues, a systematic review and meta-analysis was conducted to compare cryopreserved transfer with fresh blastocyst embryo transfer. The results show that the risk of both preterm (odds ratio [OR] 0.89, 95% confidence interval [CI] 0.80–0.99, P = 0.04) and low birthweight births (OR 0.82, 95% CI 0.68–0.99, P = 0.04) was significantly lower after cryopreserved blastocyst transfer than after fresh blastocyst transfer. The rate of large for gestational age births was significantly higher (OR 1.68, 95% CI 1.55–1.82, P < 0.00001) and the rate of small for gestational age births significantly lower (OR 0.59, 95% CI 0.54–0.65, P < 0.00001) after cryopreserved blastocyst transfer. The transfer of cryopreserved blastocysts was associated with a significantly lower risk of placental abruption (OR 0.58, 95% CI 0.40–0.83, P = 0.003) but a significantly higher risk of Caesarean section (OR 1.21, 95% CI 1.01–1.43, P = 0.03). In conclusion, the perinatal and obstetric outcomes associated with the transfer of cryopreserved blastocysts differ from those associated with fresh blastocyst transfer.

在试管婴儿中心，冷冻保存的囊胚的转移正在增加。然而，对该手术的围产期和产科结果知之甚少。为了进一步阐明这些问题，进行了系统评价和荟萃分析，以比较冷冻保存的移植与新鲜囊胚移植。结果表明，早产（比值比 [OR] 0.89，95% 置信区间 [CI] 0.80-0.99，P  = 0.04）和低出生体重儿（OR 0.82，95% CI 0.68-0.99，P  = 0.04 ）的风险) 冷冻保存的囊胚移植后显着低于新鲜囊胚移植后。大胎龄儿出生率显着更高（OR 1.68，95% CI 1.55-1.82，P < 0.00001) 并且 冷冻保存的囊胚移植后小于胎龄儿的出生率显着降低（OR 0.59，95% CI 0.54–0.65，P < 0.00001）。冷冻保存的囊胚移植与胎盘早剥风险显着降低相关（OR 0.58，95% CI 0.40-0.83，P  = 0.003），但剖宫产风险显着升高（OR 1.21，95% CI 1.01-1.43，P  = 0.03）。总之，与冷冻保存的囊胚移植相关的围产期和产科结果与新鲜囊胚移植相关的结果不同。