Objective

Frailty is a major problem in super-aged societies. Because frailty assessments are largely unstudied in acute stroke settings, few reports have evaluated the association between pre-stroke frailty and stroke severity. The aim of this study was to determine the association between pre-stroke frailty and stroke severity in elderly patients with acute stroke.

Materials and Methods

This cross-sectional study enrolled consecutive elderly patients with acute stroke. We assessed stroke severity with the National Institutes of Stroke Scale (NIHSS), and pre-stroke frailty with a Frailty Screening Index in elderly patients with acute stroke. Patients were divided according to their Frailty Screening Index: the robust group, pre-frailty group, and frailty group. Multiple linear regression analysis was used to determine whether pre-stroke frailty was independently associated with NIHSS score.

Results

In total, 234 elderly patients with acute stroke (age: 75.7 years; 149 men, 85 women) were enrolled in this study. Of these, the robust group comprised 76 patients, the pre-frailty group comprised 129 patients, and the frailty group comprised 29 patients. The prevalence of pre-stroke frailty was 12.4%. Multiple linear regression analysis showed that pre-stroke pre-frailty and frailty were significantly associated with NIHSS score (pre-frailty; β = 1.191, P = .005, frailty; β = 1.708, P = .009).

Conclusions

The present study indicated that the pre-stroke frailty was significantly associated with stroke severity in elderly patients with acute stroke. Additional study is needed to clarify the association between pre-stroke frailty and post-stroke prognosis.

中文翻译：

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老年急性卒中患者的卒中前虚弱和严重程度

目的

脆弱是超龄社会的主要问题。由于在急性卒中情况下对脆弱性评估的研究还很少，因此很少有报道评估卒中前虚弱与卒中严重程度之间的关系。这项研究的目的是确定老年急性卒中患者的卒中前虚弱与卒中严重程度之间的关系。

材料和方法

这项横断面研究招募了连续的老年急性卒中患者。我们使用国立中风学会量表（NIHSS）评估了中风的严重程度，并通过老年性卒中患者的虚弱性筛查指数评估了中风前的虚弱性。根据他们的脆弱筛查指数对患者进行划分：坚固组，脆弱前组和脆弱组。多元线性回归分析用于确定卒中前虚弱是否与NIHSS评分独立相关。

结果

本研究共纳入234例老年急性卒中患者（年龄：75.7岁；男性149名，女性85名）。其中，健壮组包括76例患者，脆弱前组包括129例患者，脆弱组包括29例患者。脑卒中前虚弱的患病率为12.4％。多元线性回归分析表明，中风前的体弱和体弱与NIHSS评分显着相关（体弱；β= 1.191，P  = .005，体弱；β= 1.708，P  = .009）。

结论

本研究表明，老年急性卒中患者的卒中前虚弱与卒中严重程度显着相关。需要进一步的研究来阐明中风前虚弱与中风后预后之间的关系。