Abstract Immunosuppressive activity guided chemical investigation, four alkaloids (1–4) and eight polyketides (5–12) were isolated from mangrove-derived Aspergillus fumigatus HQD24. Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. Compounds 1 and 3–5 were separated from mangrove endophytic fungi for the first time, 3 and 12 were firstly recovered from fungal genus Aspergillus. Compound 5 remarkable inhibited proliferation of ConA (concanavalin A)-induced T and LPS (lipopolysaccharide)-induced B murine spleen lymphocytes, with IC50 of 12.11 ± 0.11 μM and 62.66 ± 0.80 μM, respectively. Meanwhile, the chemotaxonomic relations of isolated compounds and Aspergillus species were also discussed.

中文翻译：

---

红树林内生真菌 Aspergillus fumigatus HQD24 产生的次级代谢产物具有免疫抑制活性

摘要 免疫抑制活性指导化学研究，从红树林衍生的烟曲霉 HQD24 中分离出四种生物碱 (1-4) 和八种聚酮化合物 (5-12)。基于综合光谱分析和与文献数据的比较，明确阐明了它们的结构。化合物1和3-5为首次从红树林内生真菌中分离得到，化合物3和12为首次从曲霉属真菌中分离得到。化合物 5 显着抑制了 ConA（刀豆球蛋白 A）诱导的 T 和 LPS（脂多糖）诱导的 B 鼠脾淋巴细胞的增殖，IC50 分别为 12.11 ± 0.11 μM 和 62.66 ± 0.80 μM。同时，还讨论了分离化合物与曲霉属物种的化学分类关系。