Leptin is an adipokine, adipocyte-derived compound, which acts both as a hormone and cytokine. It is mainly synthesized by adipocytes of white adipose tissue. Leptin possesses pleiotropic functions including, among others, stimulation of angiogenesis and production of proinflammatory cytokines. The various types of leptin activity are related to the wide distribution of leptin receptors. This adipokine acts by activating intracellular signaling cascades such as JAKs (Janus kinases), STATs (signal transducers and activators of transcription), and others. In a course of obesity, an increased serum level of leptin coexists with tissue receptor resistance. It has been reported that enhanced leptin levels, leptin receptor impairment, and dysfunction of leptin signaling can influence skin and hair. The previous studies revealed the role of leptin in wound healing, hair cycle, and pathogenesis of skin diseases like psoriasis, lupus erythematosus, and skin cancers. However, the exact mechanism of leptin’s impact on the skin is still under investigation. Herein, we present the current knowledge concerning the role of leptin in psoriasis and selected skin diseases.

中文翻译：

---

瘦素在特定皮肤病中的作用

瘦素是一种脂肪因子，脂肪细胞衍生的化合物，它既作为激素又作为细胞因子。它主要由白色脂肪组织的脂肪细胞合成。瘦素具有多效性功能，其中包括刺激血管生成和产生促炎细胞因子。瘦素活性的各种类型与瘦素受体的广泛分布有关。这些脂肪因子通过激活细胞内信号级联反应起作用，例如 JAK（Janus 激酶）、STAT（信号转导和转录激活剂）等。在肥胖病程中，血清瘦素水平升高与组织受体抵抗共存。据报道，瘦素水平升高、瘦素受体受损和瘦素信号传导功能障碍会影响皮肤和头发。之前的研究揭示了瘦素在伤口愈合、毛发循环和皮肤病（如银屑病、红斑狼疮和皮肤癌）发病机制中的作用。然而，瘦素对皮肤影响的确切机制仍在研究中。进来，我们介绍有关瘦素在银屑病和某些皮肤病中的作用的最新知识。