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Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2020-10-03 , DOI: 10.1039/d0tb01534b Jie Liao 1, 2, 3, 4, 5 , Bo Xu 1, 2, 3, 4, 5 , Ruihong Zhang 6, 7, 8, 9 , Yubo Fan 1, 2, 3, 4, 5 , Huiqi Xie 10, 11, 12, 13, 14 , Xiaoming Li 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2020-10-03 , DOI: 10.1039/d0tb01534b Jie Liao 1, 2, 3, 4, 5 , Bo Xu 1, 2, 3, 4, 5 , Ruihong Zhang 6, 7, 8, 9 , Yubo Fan 1, 2, 3, 4, 5 , Huiqi Xie 10, 11, 12, 13, 14 , Xiaoming Li 1, 2, 3, 4, 5
Affiliation
Decellularized materials (DMs) are attracting more and more attention because of their native structures, comparatively high bioactivity, low immunogenicity and good biodegradability, which are difficult to be imitated by synthetic materials. Recently, DMs have been demonstrated to possess great potential to overcome the disadvantages of autografts and have become a kind of promising material for tissue engineering. In this systematic review, we aimed to not only provide a quick access for understanding DMs, but also bring new ideas to utilize them more appropriately in tissue engineering. Firstly, the preparation of DMs was introduced. Then, the updated applications of DMs derived from different tissues and organs in tissue engineering were comprehensively summarized. In particular, their advantages, drawbacks and current improvements were emphasized. Moreover, we analyzed and proposed future perspectives.
中文翻译:
去细胞材料在组织工程中的应用:优点,缺点和当前改进以及未来展望
脱细胞材料(DMs)由于其天然结构,相对较高的生物活性,较低的免疫原性和良好的生物降解性而受到越来越多的关注,而合成材料难以模仿。最近,已证明DM具有克服自体移植的缺点的巨大潜力,并且已成为用于组织工程的一种有前途的材料。在这篇系统的综述中,我们的目的不仅是提供快速的了解DM的途径,而且还提出了一些新的想法来在组织工程中更适当地利用它们。首先介绍了DM的制备。然后,总结了不同组织和器官衍生的DM在组织工程中的更新应用。特别是它们的优势 强调了缺点和当前的改进。此外,我们分析并提出了未来的观点。
更新日期:2020-10-14
中文翻译:
去细胞材料在组织工程中的应用:优点,缺点和当前改进以及未来展望
脱细胞材料(DMs)由于其天然结构,相对较高的生物活性,较低的免疫原性和良好的生物降解性而受到越来越多的关注,而合成材料难以模仿。最近,已证明DM具有克服自体移植的缺点的巨大潜力,并且已成为用于组织工程的一种有前途的材料。在这篇系统的综述中,我们的目的不仅是提供快速的了解DM的途径,而且还提出了一些新的想法来在组织工程中更适当地利用它们。首先介绍了DM的制备。然后,总结了不同组织和器官衍生的DM在组织工程中的更新应用。特别是它们的优势 强调了缺点和当前的改进。此外,我们分析并提出了未来的观点。