Natriuretic peptides, BNP and ANP increase renal blood flow in experimental animals. The signalling pathway in human kidney vasculature is unknown. It was hypothesized that BNP and ANP cause endothelium‐independent relaxation of human intrarenal arteries by vascular natriuretic peptide receptor‐A, but not ‐B and ‐C, which is mimicked by agonists of soluble guanylyl cyclase sGC.

中文翻译：

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利钠肽通过可溶性鸟苷酸环化酶激动剂重现的 A 型利钠肽受体放松人肾动脉

利钠肽、BNP 和 ANP 可增加实验动物的肾血流量。人类肾脏血管系统中的信号通路尚不清楚。假设 BNP 和 ANP 通过血管利钠肽受体-A 而不是-B 和-C 引起人肾内动脉的内皮非依赖性舒张，可溶性鸟苷酸环化酶sGC 的激动剂模拟了这一点。