Microvolume blood collection technologies are of intense interest in healthcare. Whereas dried blood spots collect all the blood components, the majority of clinical tests are performed on the noncellular, plasma component of blood. Thus, there is a critical need for a robust plasma‐collecting device, which can stabilize biomarkers of interest for clinical analysis. A dried plasma spot, which consists of a separation membrane for removing red blood cells (RBC) while avoiding cell lysis and an absorbing layer for collecting and stabilizing plasma biomarkers after separation may provide such a solution. We report a novel use of electrospun polyacrylonitrile membranes to achieve a very promising separation of RBCs with near‐zero retention of human albumin protein (MW: 66.5 kDa). Physicochemical qualities of the separation membranes can be further optimized through doping and refinement of electrospinning conditions. The membranes may have future potential in microvolume sample collecting applications.

中文翻译：

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使用静电纺聚丙烯腈膜从血液中进行高回收率的采集点血浆分离

微量采血技术在医疗保健领域引起了浓厚的兴趣。干燥的血斑收集所有血液成分，而大多数临床测试是对血液的非细胞血浆成分进行的。因此，迫切需要一种坚固的血浆收集设备，该设备可以稳定用于临床分析的目标生物标志物。干燥的血浆斑点可以提供这样的解决方案，该血浆斑点由用于去除红细胞（RBC）的同时避免细胞溶解的分离膜和用于收集和稳定血浆生物标志物的吸收层组成。我们报道了一种新型的电纺聚丙烯腈膜用途，可实现非常有希望的RBC分离，并保留了人类白蛋白（MW：66.5 kDa）接近零的值。可以通过掺杂和改进电纺条件来进一步优化分离膜的理化性质。膜在微体积样品采集应用中可能具有未来的潜力。