An updated route for the asymmetric total synthesis of (+)-tronocarpine is presented. By a careful modification of the synthetic strategies and methods for the construction of azepanone ring and for the incorporation of acetyl side group at C₂₀ based on our experiences for the synthesis of chippiine-dippinine type indole alkaloids, the synthesis of (+)-tronocarpine could be shortened from 15 longest linear sequences (LLSs) to 11 LLSs starting from an easily prepared intermediate. The new synthetic route presented herein would provide a more efficient synthesis of (+)-tronocarpine as well as its analogues for biological evaluation which remained unexplored due to the paucity of natural sources.

提供了更新的路线为（+）-tronocarpine不对称全合成。根据我们合成片上碱-二哌啶型吲哚生物碱的经验，合成（+）-香豆蔻碱的经验，通过仔细修改用于构建氮杂环庚酮环和在C ₂₀引入乙酰基侧基的合成策略和方法从容易准备的中间体开始，可以将其从15个最长线性序列（LLS）缩短为11个LLS。本文提出的新的合成途径将提供更有效的（+）-香豆碱及其类似物的合成，以用于生物学评估，由于缺乏天然来源，该合成途径仍未开发。