Cisplatin has demonstrated extraordinary anticancer activity against a variety of solid tumors. However, its clinical efficacy is contrasted by its toxicity profile. Having in mind the need to reduce the toxicity, promote a sustained release and enhance the body-circulation time of cisplatin, herein novel nanocarriers consisting of core–shell silica-coated iron oxide nanoparticles functionalized with dicarboxylic acid groups were prepared and characterized. Cisplatin was conjugated with the functionalized nanoparticles by surface tethering. Controlled release of cisplatin was observed without burst effect and in a sustained profile for up to 3 days. In vitro studies showed cytotoxic and antiproliferative effects of the cisplatin nanoconjugates against a human pancreatic cancer cell line. Importantly, when compared with free cisplatin, nanoconjugates exhibited lower cytotoxic effects regarding nonmalignant human duct pancreatic cells.

顺铂已显示出对多种实体瘤的非凡抗癌活性。但是，其临床疗效却被其毒性特征所对比。考虑到需要减少毒性，促进持续释放并延长顺铂的体内循环时间，在此制备并表征了由以二羧酸基团官能化的核-壳二氧化硅包覆的氧化铁纳米颗粒组成的新型纳米载体。通过表面束缚将顺铂与官能化的纳米颗粒偶联。观察到顺铂的控释没有爆发效应，并且持续长达3天。体外研究表明，顺铂纳米偶联物对人胰腺癌细胞系具有细胞毒性和抗增殖作用。重要的是，当与游离顺铂相比时，纳米缀合物对非恶性人导管胰腺细胞显示出较低的细胞毒性作用。