This study appraises pharmaceutical potential and phenolics profiling of various solvent extracts gained from bark and leaves of Calotropis procera plant. The extracts were obtained using various solvents including CH3OH, C4H8O2, CHCl3 (50 and 100% for each) and H2O. The extracts were evaluated for antioxidant potential, antibacterial, antianti-glycation and anti-inflammatory activities. The yield of extracts ranged from 5.61 to 48.16% of dry weight (DW) for different extraction solvents. The highest percentage extract yield was obtained with 100% CH3OH from leaves. Various solvent extracts from C. procera leaves and bark exhibited considerable total phenolic content (20.41 to 100.18 GAE mg/g DW and total flavonoid content (IC50 18.33 to 92.92 CE mg/g DW), radical scavenging activity (1.03 to 7.42 mg/mL) and reducing power (EC50 525.65 to 1157.74 mg/mL). The tested extracts showed notable antibacterial potential against bacterial strains such as Klebsiella pneumonia, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli. The maximum antioxidant and antibacterial activities were exhibited by methanol extracts from both tested parts of C. procera plant. However, the anti-inflammatory activity (45.45% inhibition) was observed to be higher for 50% chloroform extract from the leaves. HPLC analysis established that the leaves and bark of C. procera contained considerable amounts of natural antioxidants such as sinapic acid (17.3 ± 2.11 to 9586.44 ± 0.78 mg kg-1), vanillic acid (9.43 ± 0.21 to 5051.7 ± 18.47 mg kg-1) and protocatechuic acid (2.46 ± 0.40 to 139.05 ± 1.37 mg kg-1). All extracts from the tested materials did not exhibit significant anti-glycation activity. Generally, the extracts from leaves of C. procera offered higher levels of phenolic acids and biological activities than the bark extracts.

中文翻译：

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与提取溶剂相关的 Calotropis Procera 叶和树皮的药学潜力和酚类分析

本研究评估了从 Calotropis procera 植物的树皮和叶子中提取的各种溶剂提取物的药物潜力和酚类物质分析。提取物是使用各种溶剂获得的，包括 CH3OH、C4H8O2、CHCl3（各为 50% 和 100%）和 H2O。评估提取物的抗氧化潜力、抗菌、抗糖化和抗炎活性。对于不同的提取溶剂，提取物的产量为干重 (DW) 的 5.61% 至 48.16%。使用 100% CH3OH 从叶子中获得最高百分比的提取物产量。C. procera 叶和树皮的各种溶剂提取物表现出相当大的总酚含量（20.41 至 100.18 GAE mg/g DW 和总黄酮含量（IC50 18.33 至 92.92 CE mg/g DW），自由基清除活性（1.03 至 7.42 mg/mL） ) 和降低功率 (EC50 525.65 至 1157。74 毫克/毫升）。测试的提取物对细菌菌株显示出显着的抗菌潜力，如肺炎克雷伯菌、铜绿假单胞菌、枯草芽孢杆菌和大肠杆菌。来自 C. procera 植物的两个测试部分的甲醇提取物表现出最大的抗氧化和抗菌活性。然而，观察到来自叶子的 50% 氯仿提取物的​​抗炎活性（45.45% 抑制）更高。HPLC 分析确定，C. procera 的叶子和树皮含有大量天然抗氧化剂，例如芥子酸（17.3 ± 2.11 至 9586.44 ± 0.78 mg kg-1）、香草酸（9.43 ± 0.21 至 5051.7 ± 18.47 mg kg-1） ) 和原儿茶酸 (2.46 ± 0.40 至 139.05 ± 1.37 mg kg-1)。来自测试材料的所有提取物均未表现出显着的抗糖化活性。一般来说，