This work aimed at comparing two different microfluidic-assisted nanoparticles (NPs) based on poly(ɛ-caprolactone) (PCL) and cellulose acetate (CA) in terms of size, size distribution, and morphology by changing the flow rate ratios and surfactants. At the same polymer solutions concentration [0.05 (%w/v)], the DLS and FE-SEM results showed that CA NPs have the average diameter (~ 37 nm) and PDI (0.035) less than PCL ones. It was also found that the change of surface tension between the polymers and non-solvent phases using poly(vinyl alcohol) or Tween 80 could remarkably increase the diameter of PCL NPs. Finally, the impact of channel length as a function of mixing efficiency on the size of NPs was theoretically discussed via Reynolds and Peclet numbers. The results indicated that the Peclet numbers pertaining to the required length and time of mixing were more than 100, leading to the smaller channel length for effective mixing.

中文翻译：

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聚（ɛ-己内酯）和醋酸纤维素纳米粒子的微流体辅助生产：聚合物、表面活性剂和流速比的影响

这项工作旨在通过改变流速比和表面活性剂，在尺寸、尺寸分布和形态方面比较基于聚（ε-己内酯）（PCL）和醋酸纤维素（CA）的两种不同的微流体辅助纳米颗粒（NP）。在相同的聚合物溶液浓度 [0.05 (%w/v)] 下，DLS 和 FE-SEM 结果表明 CA NPs 的平均直径 (~ 37 nm) 和 PDI (0.035) 小于 PCL 的。还发现使用聚乙烯醇或吐温 80 的聚合物和非溶剂相之间的表面张力变化可以显着增加 PCL NPs 的直径。最后，通过雷诺数和佩克莱数从理论上讨论了通道长度作为混合效率函数对 NP 大小的影响。