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Comparison of surgical outcomes in cystic and solid vestibular schwannomas: a systematic review and meta-analysis
Neurosurgical Review ( IF 2.8 ) Pub Date : 2020-10-02 , DOI: 10.1007/s10143-020-01400-5
Xiaolong Wu 1, 2 , Gang Song 1, 2 , Xu Wang 1, 2 , Mingchu Li 1, 2 , Ge Chen 1, 2 , Hongchuan Guo 1, 2 , Yuhai Bao 1, 2 , Jiantao Liang 1, 2
Affiliation  

Most studies reported that cystic vestibular schwannoma (CVS) surgery has a less favourable prognosis than solid vestibular schwannoma (SVS) surgery. However, some studies report that it is unclear whether surgical outcomes for these conditions exhibit significant differences. The aim of this meta-analysis was to pool the current literature and describe and analyse any differences in the clinical symptoms and surgical outcomes among CVS and SVS. PubMed, Embase, and Cochrane databases were searched following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines through April 22, 2020. Outcomes were analysed using a meta-analysis of the proportions. The results of the search yielded 17 studies that met the criteria for inclusion and analysis, involving 3074 participants (including 821 patients with CVSs and 2253 patients with SVSs). No significant differences in the extent of tumour resection (gross-total resection versus non-gross-total resection; RR, 0.93; 95% CI, 0.86–1.01; p = 0.096) and most other outcomes were noted between CVS and SVS cohorts. However, facial nerve function (House-Brackmann Grade I or II versus III or more) of CVS patients was worse (RR, 0.86; 95% CI, 0.78–0.93; p < 0.001) compared with SVS patients with more than 1 year of follow-up after surgery. The criteria of cystic acoustic neuroma needs to be further unified, and prospective cohort studies with larger sample sizes should be performed for further verification of these results in the future.



中文翻译:

囊性和实性前庭神经鞘瘤手术结果的比较:系统评价和荟萃分析

大多数研究报告说,囊性前庭神经鞘瘤 (CVS) 手术的预后不如实体性前庭神经鞘瘤 (SVS) 手术。然而,一些研究报告说,尚不清楚这些疾病的手术结果是否表现出显着差异。本荟萃分析的目的是汇集现有文献,描述和分析 CVS 和 SVS 之间临床症状和手术结果的任何差异。在 2020 年 4 月 22 日之前,按照系统评价和元分析的首选报告项目指南搜索了 PubMed、Embase 和 Cochrane 数据库。使用比例的元分析来分析结果。搜索结果产生了 17 项符合纳入和分析标准的研究,涉及 3074 名参与者(包括 821 名 CVS 患者和 2253 名 SVS 患者)。肿瘤切除的范围无显着差异(全切除与非全切除;RR,0.93;95% CI,0.86–1.01;p  = 0.096) 并且在 CVS 和 SVS 队列之间注意到大多数其他结果。然而, 与 1 年以上的 SVS 患者相比,CVS 患者的面神经功能(House-Brackmann 等级 I 或 II 与 III 级或更高)更差(RR,0.86;95% CI,0.78-0.93;p < 0.001)。手术后的随访。囊性听神经瘤的诊断标准有待进一步统一,未来应进行更大样本量的前瞻性队列研究以进一步验证这些结果。

更新日期:2020-10-04
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