Glioma is the prevalent aggressive primary brain tumor, with a very poor prognosis. The absence of advanced understanding of the roles played by the cells within the glioma microenvironment limits the development of effective drugs. A recent study indicates that periostin expressed by pericytes is crucial for glioma angiogenesis. Here, we describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment. The emerging knowledge from this work will benefit the development of therapies for gliomas.

中文翻译：

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胶质瘤周细胞通过产生骨膜素促进血管生成

神经胶质瘤是普遍存在的侵袭性原发性脑肿瘤，预后极差。缺乏对神经胶质瘤微环境中细胞所起作用的深入了解限制了有效药物的开发。最近的一项研究表明，由周细胞表达的骨膜蛋白对于神经胶质瘤血管生成至关重要。在这里，我们简明扼要地描述了这一发现在我们对神经胶质瘤微环境中周细胞的了解中的结果和意义。这项工作的新兴知识将有利于神经胶质瘤疗法的发展。