Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.

中文翻译：

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COVID-19：分子靶点、药物再利用和药物发现的新途径

由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的 2019 冠状病毒病 (COVID-19) 是一种高度传染性的感染，可能会破坏多个国家的医疗保健系统。在此，我们旨在对正在进行的 COVID-19 药物再利用工作提出批判性观点，并根据当前对感染机制和潜在靶标的了解，讨论开发新疗法的机会。最后，我们还讨论了一些研究最多的再利用候选药物的合成路线的专利保护问题、成本效益和可扩展性，因为这些是满足全球对 COVID-19 治疗需求的关键方面。