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Caenorhabditis elegans in anthelmintic research – Old model, new perspectives
International Journal for Parasitology: Drugs and Drug Resistance ( IF 4 ) Pub Date : 2020-10-02 , DOI: 10.1016/j.ijpddr.2020.09.005
Steffen R Hahnel 1 , Clayton M Dilks 2 , Iring Heisler 1 , Erik C Andersen 2 , Daniel Kulke 1
Affiliation  

For more than four decades, the free-living nematode Caenorhabditis elegans has been extensively used in anthelmintic research. Classic genetic screens and heterologous expression in the C. elegans model enormously contributed to the identification and characterization of molecular targets of all major anthelmintic drug classes. Although these findings provided substantial insights into common anthelmintic mechanisms, a breakthrough in the treatment and control of parasitic nematodes is still not in sight. Instead, we are facing increasing evidence that the enormous diversity within the phylum Nematoda cannot be recapitulated by any single free-living or parasitic species and the development of novel broad-spectrum anthelmintics is not be a simple goal. In the present review, we summarize certain milestones and challenges of the C. elegans model with focus on drug target identification, anthelmintic drug discovery and identification of resistance mechanisms. Furthermore, we present new perspectives and strategies on how current progress in C. elegans research will support future anthelmintic research.



中文翻译:

蠕虫研究中的秀丽隐杆线虫——旧模型,新视角

四十多年来,自由生活的线虫秀丽隐杆线虫已广泛用于驱虫研究。线虫模型中的经典遗传筛选和异源表达极大地促进了所有主要驱虫药物类别的分子靶标的鉴定和表征。尽管这些发现提供了对常见驱虫机制的重要见解,但仍然看不到在寄生线虫的治疗和控制方面取得突破。相反,我们正面临越来越多的证据表明线虫门内的巨大多样性不能被任何单一的自由生活或寄生物种概括,开发新型广谱驱虫药也不是一个简单的目标。在本综述中,我们总结了秀丽隐杆线虫模型的某些里程碑和挑战,重点是药物靶点识别、驱虫药物发现和耐药机制的识别。此外,我们就当前线虫研究的进展将如何支持未来的驱虫研究提出了新的观点和策略。

更新日期:2020-11-27
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