Abstract Cellulose-based hydrogel materials were prepared and modified with tannic acid and l -methionine using ionic liquid as the solvent. The gels were prepared to develop a sustained release medium for selenourea (SeU). The drug delivery characteristics of selenourea-loaded cellulose (CSeU), selenourea-loaded tannic acid-modified cellulose (CTSeU), and selenourea-loaded L-methionine-modified cellulose (CMSeU) were investigated in aqueous media and simulated gastric fluid (SGF) media. This modified gel beads have been characterized using field emission scanning electron microscope, X-ray energy-dispersive spectroscopy, Fourier transform infrared spectroscopy, thermogravimetry–differential thermal analysis and swelling properties and compared with those of the unmodified ones. We also investigated the inhibitory effects of SeU released from these gels on the activity of mushroom tyrosinase. Out of all the gel materials, CTSeU showed maximum SeU release both in water and SGF media. However, tyrosinase inhibitory action in PBS medium was comparable for all the three gel materials.

中文翻译：

---

用于加载和缓释硒脲的离子液体改性纤维素水凝胶：随后抑制酪氨酸酶活性

摘要 以离子液体为溶剂，以单宁酸和L-甲硫氨酸为原料制备并改性纤维素基水凝胶材料。制备凝胶以开发硒脲 (SeU) 的缓释介质。在水性介质和模拟胃液 (SGF) 中研究了硒脲负载纤维素 (CSeU)、硒脲负载单宁酸改性纤维素 (CTSeU) 和硒脲负载 L-蛋氨酸改性纤维素 (CMSeU) 的药物递送特性媒体。这种改性凝胶珠已使用场发射扫描电子显微镜、X 射线能量色散光谱、傅里叶变换红外光谱、热重-差热分析和溶胀特性进行表征，并与未改性的凝胶珠进行比较。我们还研究了从这些凝胶中释放的 SeU 对蘑菇酪氨酸酶活性的抑制作用。在所有凝胶材料中，CTSeU 在水和 SGF 介质中都显示出最大的 SeU 释放。然而，对于所有三种凝胶材料，PBS 培养基中的酪氨酸酶抑制作用相当。