Trisomy 3 has been previously reported in association with T-cell lymphomas and less commonly in different types of non-Hodgkin B-cell lymphomas. Trisomy 3 has also been reported in two cases of pediatric post-transplant lymphoproliferative disorder (PTLD). We present comprehensive clinicopathologic review of two pediatric patients with cardiac and liver/intestinal allografts that developed polymorphic PTLD characterized by trisomy 3. Both patients had Epstein-Barr virus (EBV) viremia and EBV was positive in tissue by EBER in situ hybridization. Using karyotype analysis and fluorescence in situ hybridization, we identified trisomy 3 in both patients. Both patients responded to treatment and are now free of the PTLD. Trisomy 3, an uncommon cytogenetic finding in pediatric polymorphic PTLD, may be a recurrent cytogenetic aberration if confirmed in a larger study of pediatric PTLDs. Further clinical follow up might help stratify significance of trisomy 3 as a prognostic factor.

先前已经报道了三体性三联体与T细胞淋巴瘤相关，在不同类型的非霍奇金B细胞淋巴瘤中较少见。在三例小儿移植后淋巴细胞增生性疾病（PTLD）中也已经报道了三体性3。我们目前对两名患有心脏和肝脏/肠道同种异体移植的小儿患者进行全面的临床病理检查，这些小儿患者具有三体性特征的多态性PTLD。这两名患者均患有爱泼斯坦-巴尔病毒（EBV）病毒血症，并且通过EBER原位杂交在组织中EBV呈阳性。使用核型分析和原位荧光  杂交，我们在这两名患者中均确定了三体性3。两名患者对治疗均有效，并且现在没有PTLD。如果在较大的儿科PTLD研究中得到证实，三体性3是儿童多态性PTLD中罕见的细胞遗传学发现，可能是复发性细胞遗传学异常。进一步的临床随访可能有助于将三体性3作为预后因素的意义进行分层。