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Molybdenum cofactor biology, evolution and deficiency
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ( IF 5.1 ) Pub Date : 2020-10-02 , DOI: 10.1016/j.bbamcr.2020.118883
Simon J. Mayr , Ralf-R. Mendel , Guenter Schwarz

The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global scale. Given the diversity of biological processes dependent on Moco and their evolutionary age, Moco is traced back to the last universal common ancestor (LUCA), while Moco biosynthetic genes underwent significant changes through evolution and acquired additional functions. In this review, focused on eukaryotic Moco biology, we elucidate the benefits of gene fusions on Moco biosynthesis and beyond. While originally the gene fusions were driven by biosynthetic advantages such as coordinated expression of functionally related proteins and product/substrate channeling, they also served as origin for the development of novel functions. Today, Moco biosynthetic genes are involved in a multitude of cellular processes and loss of the according gene products result in severe disorders, both related to Moco biosynthesis and secondary enzyme functions.



中文翻译:

钼辅因子的生物学,进化与缺乏

钼辅助因子(Moco)代表一种古老的金属硫辅助因子,在单个和全球范围内,它作为催化剂参与碳,氮和硫的循环。鉴于依赖于Moco的生物过程及其进化年龄的多样性,Moco可以追溯到最后一个通用祖先(LUCA),而Moco的生物合成基因通过进化经历了重大变化并获得了额外的功能。在这篇综述中,我们着重于真核Moco生物学,我们阐明了基因融合在Moco生物合成及其他方面的益处。尽管最初的基因融合是由生物合成优势驱动的,例如功能相关蛋白的协同表达和产物/底物的通道化,但它们还是新功能开发的起点。今天,

更新日期:2020-10-15
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