To better assess the risk of microplastics (MPs) as a vector for contaminants, it is essential to understand the relative importance of MPs compared to other pathways for chemical transfer as well as the consequences of co-exposure. In this study, we exposed Japanese medaka (Oryzias latipes) to anthracene (ANT, 0.1 mg/L) in the presence or absence of pristine polyethylene MPs (PE-MPs, 10⁶ beads/L), to quantify the vector effect of PE-MPs on ANT accumulation. Under the ANT-MPs co-exposure conditions, PE-MPs rapidly accumulated in the gastrointestinal tract of the medaka during a 14-day uptake phase, with an average bioconcentration factor of 171.4 L/kg. The PE-MPs could absorb and accumulate approximately 70 % of the ANT from the water sample. The PE-MPs changed the pharmacokinetic profile of ANT in medaka by decreasing both the uptake and depuration rate constants. The one compartment with first-order elimination model estimated that the amounts of ANT in the water phase and absorbed by PE-MPs (i.e., a vector effect) contributed about 67 % and 33 % of the ANT accumulation in medaka, respectively. At the end of the uptake (exposure) phase, however, the presence of PE-MPs did not significantly alter the final ANT concentrations in the fish body or alter the behavioral impacts of ANT. Thus, PE-MPs ingestion may act as a vector to concentrate and transfer ANT to medaka, but the presence of these particles may have limited adverse effects on fish under co-exposure systems of the type used in this study.

为了更好地评估作为污染物载体的微塑料（MPs）的风险，必须了解与其他化学传递途径相比，MPs的相对重要性以及共同暴露的后果。在这项研究中，我们在存在或不存在原始聚乙烯MPs（PE-MPs，10 ⁶）的情况下，将日本（Oryzias latipes）暴露于蒽（ANT，0.1 mg / L）中。珠/ L），以量化PE-MP对ANT积累的载体作用。在ANT-MPs共同暴露条件下，PE-MPs在14天摄取阶段迅速积聚在青的胃肠道中，平均生物富集系数为171.4 L / kg。PE-MP可以吸收和积累水样品中约70％的ANT。PE-MP通过降低摄取率和净化率常数来改变ANT在青aka中的药代动力学特征。具有一阶消除模型的一个隔室估计，水相中的ANT量和被PE-MP吸收（即媒介效应）分别对medaka中的ANT积累贡献了67％和33％。但是，在摄取（接触）阶段结束时，PE-MPs的存在不会显着改变鱼体内最终ANT的浓度或改变ANT的行为影响。因此，PE-MPs的摄取可作为将ANT浓缩并将其转移至medaka的载体，但是在本研究使用的共同暴露系统下，这些颗粒的存在可能对鱼类产生有限的不利影响。