With the development and rising of antimicrobial resistance, rapid and effective killings of bacteria are urgently needed, especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be treated with conventional antibiotics. Here, a rapid and broad-spectrum antibacterial strategy is demonstrated through photothermal ablation with MXene and light. Ti₃C₂ MXenes, when combined with 808 nm light, show significant antibacterial effects in just 20 min. The antibacterial strategy is effective to 15 bacterial species tested, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). In addition, the rapid antibacterial strategy works for MRSA biofilms, by damaging the structures as well as killing bacteria in biofilms. Furthermore, the investigation of the antibacterial mechanisms shows that Ti₃C₂ with light kills bacteria mainly physically through inserting/contact and photothermal effect. This work broadens the potential applications of MXene and provides a way to eradicate bacteria and biofilms physically, without the likelihood of resistance development.

随着抗微生物剂耐药性的发展和提高，迫切需要快速有效地杀死细菌，特别是对于通常难以用常规抗生素治疗的抗生素抗性细菌和细菌生物膜。在这里，通过用MXene和光进行光热消融，证明了一种快速且广谱的抗菌策略。Ti ₃ C ₂ MXenes与808 nm光组合时，仅20分钟即可显示出显着的抗菌效果。该抗菌策略对15种受测细菌有效，包括耐甲氧西林的金黄色葡萄球菌（MRSA）和耐万古霉素的肠球菌（VRE）。另外，通过破坏结构并杀死生物膜中的细菌，快速抗菌策略适用于MRSA生物膜。此外，对抗菌机理的研究表明，带有光的Ti ₃ C ₂主要通过插入/接触和光热作用在物理上杀死细菌。这项工作拓宽了MXene的潜在应用范围，并提供了一种物理消灭细菌和生物膜的方法，而不会产生耐药性。