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Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid
AMB Express ( IF 3.7 ) Pub Date : 2020-10-02 , DOI: 10.1186/s13568-020-01117-0 Annett Mikolasch , Elke Hammer , Sabine Witt , Ulrike Lindequist
中文翻译:
漆酶催化的6-氨基青霉,7-氨基头孢烷酸和7-氨基去乙酰氧基头孢菌酸的衍生化
更新日期:2020-10-02
AMB Express ( IF 3.7 ) Pub Date : 2020-10-02 , DOI: 10.1186/s13568-020-01117-0 Annett Mikolasch , Elke Hammer , Sabine Witt , Ulrike Lindequist
Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains.
中文翻译:
漆酶催化的6-氨基青霉,7-氨基头孢烷酸和7-氨基去乙酰氧基头孢菌酸的衍生化
Trametes规格 漆酶(EC 1.10.3.2。)介导6-氨基青霉素,7-氨基头孢烷酸和7-氨基去乙酰氧基头孢菌酸与2,5-二羟基苯甲酸衍生物的氧化偶联分别形成新的青霉素和头孢菌素结构。异分子杂合二聚体是通过对氢苯醌与伯胺的核胺化作用形成的,并在体外抑制葡萄球菌菌种的生长,包括一些耐多药菌株。