Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury to varying degrees. In spinal cord injury models, some inflammatory cytokines are beneficial for spinal cord repair, while others are harmful. A large number of animal studies have shown that local targeted administration can effectively regulate the secretion and delivery of inflammatory cytokines and promote the repair of spinal cord injury. In addition, many clinical studies have shown that drugs can promote the repair of spinal cord injury by regulating the content of inflammatory cytokines. However, topical administration affects only a small portion of inflammatory cytokines. In addition, different individuals have different inflammatory cytokine profiles during spinal cord injury. Therefore, future research should aim to develop a personalized local delivery therapeutic cocktail strategy to effectively and accurately regulate inflammation and obtain substantial functional recovery from spinal cord injury.

中文翻译：

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炎症细胞因子对脊髓损伤恢复的调节。

脊髓损伤（SCI）是人类最具破坏性的创伤性疾病之一。微环境中炎症的平衡对脊髓损伤的修复过程至关重要。炎性细胞因子是局部病变炎症的直接介质，不同程度地影响脊髓损伤的预后。在脊髓损伤模型中，一些炎性细胞因子对脊髓修复有益，而另一些则有害。大量动物研究表明，局部靶向给药可有效调节炎性细胞因子的分泌和传递，促进脊髓损伤的修复。此外，许多临床研究表明，药物可以通过调节炎性细胞因子的含量来促进脊髓损伤的修复。然而，局部给药仅影响一小部分炎性细胞因子。此外，不同的个体在脊髓损伤期间具有不同的炎性细胞因子谱。因此，未来的研究应旨在开发一种个性化的局部给药治疗鸡尾酒策略，以有效准确地调节炎症并从脊髓损伤中获得实质性的功能恢复。