A 66-year-old woman with no relevant medical history presented at the emergency department with new-onset atrial fibrillation. We initiated intravenous amiodarone therapy. At 20 hours, the patient experienced severe neurologic symptoms, hyponatremia, and syndrome of inappropriate antidiuretic hormone. We discontinued amiodarone, infused saline solution, and restricted the patient's fluid intake. She recovered in 3 days. This case illustrates that amiodarone-induced syndrome of inappropriate antidiuretic hormone with hyponatremia can occur far earlier than expected during acute amiodarone therapy.

中文翻译：

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胺碘酮治疗20小时后精神状态和低钠血症改变

一名没有相关病史的66岁妇女在急诊科就诊，伴有新发房颤。我们启动了静脉胺碘酮治疗。在20小时时，患者经历了严重的神经系统症状，低钠血症和不适当的抗利尿激素综合征。我们终止了胺碘酮的治疗，注入了盐溶液，并限制了病人的液体摄入量。她在三天内康复。该病例说明，胺碘酮引起的低钠抗利尿激素不适当综合征可能比急性胺碘酮治疗期间发生的早得多。