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Letter to the Editor: Response to Luke Fletcher and Philip Peyton regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients”
Intensive Care Medicine Experimental Pub Date : 2020-10-01 , DOI: 10.1186/s40635-020-00342-y
Emma M. Chang , Andrew Bretherick , Gordon B. Drummond , J. Kenneth Baillie

To the Editor,

We thank Peyton and Fletcher for their interest in our paper, where we devised a method to infer shunt fraction from a single arterial blood gas sample, with the intention to allow clinical research and prediction without the need for additional invasive measurements, as stated both in the abstract and the main text of our report. Peyton and Fletcher have usefully emphasised this point by citing their own work, in which more invasive samples could be taken. However, it is very likely that the correct derivation of the relationship between the relevant components of the equation has been known and used well before this work: see, for example, the diagrammatic explanation shown in our citation 2 [1]. We do not claim that this simple algebraic rearrangement is original.

As we stated in our paper, our conclusion is that the estimated shunt fraction, although imperfect, is an improvement upon P/F. We recommend its use instead of other measures in situations where FIO2 is changing.

We thank the authors for spotting the typo in one of the equations in our paper on Effective Shunt (ES). A set of parentheses were dropped in the published version. We have now corrected this.

Best wishes,

Emma Chang, Andrew Bretherick, Gordon Drummond and Kenneth Baillie

Not applicable

  1. 1.

    Drummond GB, Zhong NS (1983) Inspired oxygen and oxygen transfer during artificial ventilation for respiratory failure. British journal of anaesthesia. 55:3–13

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Affiliations

  1. Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK

    Emma M. Chang, Andrew Bretherick, Gordon B. Drummond & J. Kenneth Baillie

  2. MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, EH4 2XU, UK

    Andrew Bretherick

  3. The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, EH25 9RG, UK

    J. Kenneth Baillie

Authors
  1. Emma M. ChangView author publications

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  2. Andrew BretherickView author publications

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  3. Gordon B. DrummondView author publications

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  4. J. Kenneth BaillieView author publications

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Contributions

All authors commented and contributed to the final response. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to J. Kenneth Baillie.

Ethics approval and consent to participate

As this is a response to a letter on our previous work, ethical approval and consent were not required.

Consent for publication

Not applicable

Competing interests

All authors state that they have no potential conflicts of interest to declare relating to this work.

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Chang, E.M., Bretherick, A., Drummond, G.B. et al. Letter to the Editor: Response to Luke Fletcher and Philip Peyton regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients”. ICMx 8, 57 (2020). https://doi.org/10.1186/s40635-020-00342-y

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  • DOI: https://doi.org/10.1186/s40635-020-00342-y

中文翻译：
致编辑的信：对卢克·弗莱彻（Luke Fletcher）和菲利普·佩顿（Philip Peyton）的答复：“对危重患者有效分流比的新型无创估计的预测有效性”

致编辑

我们感谢Peyton和Fletcher对我们的论文的兴趣，在该论文中，我们设计了一种从单个动脉血气样本中推断出分流分数的方法，旨在允许进行临床研究和预测而无需进行额外的侵入性测量，报告的摘要和正文。Peyton和Fletcher通过引用他们自己的工作来有效地强调了这一点，在该工作中可以采取更具侵入性的样本。但是，很可能在这项工作之前就已经知道并正确使用了方程式相关组件之间关系的正确推导：例如，参见我们引文2 [1]中所示的图解说明。我们不认为这种简单的代数重排是原始的。

如我们在论文中所述，我们的结论是，尽管分流比不理想，但它是P / F的改进。我们建议在FIO2发生变化的情况下使用它而不是其他措施。

我们感谢作者在我们关于有效分流（ES）的论文中发现方程式之一的错字。在发布的版本中删除了一组括号。我们现在已更正此问题。

最好的祝愿，

艾玛·张（Emma Chang），安德鲁·布雷特里克（Andrew Bretherick），戈登·德拉蒙德（Gordon Drummond）和肯尼斯·贝利

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  1. 1。

    Drummond GB，Zhong NS（1983）在呼吸衰竭的人工通气中吸取了氧气和氧气。英国麻醉杂志。55：3–13

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隶属关系

  1. 麻醉，重症监护和疼痛医学，爱丁堡皇家医院，爱丁堡，EH16 4SA，英国

    Emma M. Chang，Andrew Bretherick，Gordon B.Drummond和J.Kenneth Baillie

  2. 爱丁堡大学MRC遗传与分子医学研究所，英国爱丁堡EH4 2XU

    安德鲁·布雷特里克

  3. 爱丁堡大学罗斯林研究所和皇家（迪克）兽医学院，复活节布什，爱丁堡，EH25 9RG，英国

    肯尼思·贝利

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  1. Emma M. Chang查看作者出版物

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  2. 安德鲁·布雷特里克（Andrew Bretherick）查看作者出版物

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  3. Gordon B. Drummond查看作者出版物

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  4. J. Kenneth Baillie查看作者出版物

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对应于J. Kenneth Baillie。

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Chang，EM，Bretherick，A.，Drummond，GB等。致编辑的信：对卢克·弗莱彻（Luke Fletcher）和菲利普·佩顿（Philip Peyton）的答复：“对危重患者有效分流比的新型无创估计的预测有效性”。ICMx 8， 57（2020）。https://doi.org/10.1186/s40635-020-00342-y

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  • DOI ：https ：//doi.org/10.1186/s40635-020-00342-y
更新日期：2020-10-02
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