Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China,Environmental Health Perspectives

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Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China
Environmental Health Perspectives ( IF 10.4 ) Pub Date : 2020-9-30 , DOI: 10.1289/ehp7076
Peipei Hu ₁ , Angela Vinturache ₂ , Hong Li ₃ , Ying Tian _{4,

5} , Lei Yuan ₄ , Chen Cai ₁ , Min Lu ₁ , Jiuru Zhao _{6,

7} , Qianqian Zhang _{6,

7} , Yu Gao ₄ , Zhiwei Liu ₈ , Guodong Ding ₁

Affiliation

Department of Respiratory Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai, China
Department of Obstetrics & Gynecology, Queen Elizabeth II Hospital, Alberta, Canada
Departments of Nursing, International Peace Maternity and Children Hospital of China Welfare Institution, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
Departments of Neonatology, International Peace Maternity and Children Hospital of China Welfare Institution, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Abstract

Background:

Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies.

Objectives:

This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population.

Methods:

This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes.

Results:

Compared with women in the lowest quartile ( $Uppercase q begin subscript 1 end subscript$ ) of individual DEP and $summation begin subscript 4 end subscript of dialkylphosphate$ (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile ( $Uppercase q begin subscript 4 end subscript$ ) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant ( $lowercase italic p-trends less than 0.05$ ). There were no significant associations between urinary DAP concentrations and early IVF outcomes, including total and mature oocyte counts, best embryo quality, fertilization, $Uppercase e begin subscript 2 end subscript$ trigger levels, and endometrial wall thickness.

Conclusion:

Preconception OP exposure was inversely associated with successful implantation, clinical pregnancy, and live birth in women who underwent IVF. https://doi.org/10.1289/EHP7076

更新日期：2020-10-02

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