A 6-y-old, 3.5-kg, spayed female Toy Poodle was presented with left forelimb lameness of 2-d duration. Two months before the initial presentation, radiography showed osteolysis of the medial epicondyle of the left humerus, and the left forelimb was amputated. Grossly, the articular villi of the elbow joint were markedly thickened, and the articular cartilage surfaces of the distal humerus and proximal radius had partial erosion. Histologically, granulomatous arthritis and osteomyelitis characterized by the presence of abundant macrophages containing numerous fungi were observed. ITS and β-tubulin sequences amplified from the isolate from the specimen were 100% and 99% identical to type strain UTHSC D16-145^T of Talaromyces georgiensis, respectively. Canine osteoarthritis caused by T. georgiensis has not been reported previously, to our knowledge.

一只 6 岁、3.5 公斤、已绝育的雌性玩具贵宾犬出现左前肢跛行持续 2 天。在初次就诊前两个月，X 光片显示左肱骨内上髁骨质溶解，左前肢被截肢。大体上肘关节关节绒毛明显增厚，肱骨远端和桡骨近端关节软骨面有部分糜烂。在组织学上，观察到肉芽肿性关节炎和骨髓炎，其特征是存在大量含有大量真菌的巨噬细胞。从标本的分离物中扩增的 ITS 和 β-微管蛋白序列分别与Talaromyces georgiensis 的类型菌株 UTHSC D16-145 ^T具有100% 和 99% 的同一性。犬骨关节炎引起的据我们所知，T. georgiensis以前没有被报道过。