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Adintoviruses: A Proposed Animal-Tropic Family of Midsize Eukaryotic Linear dsDNA (MELD) Viruses
Virus Evolution ( IF 5.3 ) Pub Date : 2020-10-01 , DOI: 10.1093/ve/veaa055
Gabriel J Starrett 1 , Michael J Tisza 1 , Nicole L Welch 1 , Anna K Belford 1 , Alberto Peretti 1 , Diana V Pastrana 1 , Christopher B Buck 1
Affiliation  

Polintons (also known as Mavericks) were initially identified as a widespread class of eukaryotic transposons named for their hallmark type B DNA polymerase and retrovirus-like integrase genes. It has since been recognized that many polintons encode possible capsid proteins and viral genome-packaging ATPases similar to those of a diverse range of double-stranded DNA (dsDNA) viruses. This supports the inference that at least some polintons are actually viruses capable of cell-to-cell spread. At present, there are no polinton-associated capsid protein genes annotated in public sequence databases. To rectify this deficiency, we used a data-mining approach to investigate the distribution and gene content of polinton-like elements and related DNA viruses in animal genomic and metagenomic sequence datasets. The results define a discrete family-like clade of viruses with two genus-level divisions. We propose the family name Adintoviridae, connoting similarities to adenovirus virion proteins and the presence of a retrovirus-like integrase gene. Although adintovirus-class PolB sequences were detected in datasets for fungi and various unicellular eukaryotes, sequences resembling adintovirus virion proteins and accessory genes appear to be restricted to animals. Degraded adintovirus sequences are endogenized into the germlines of a wide range of animals, including humans.

中文翻译:

Adintoviruses:一个拟议的动物热带中型真核线性 dsDNA (MELD) 病毒家族

Polintons(也称为 Mavericks)最初被鉴定为一类广泛分布的真核转座子,以其标志性的 B 型 DNA聚合酶和逆转录病毒样整合酶基因命名。此后人们认识到,许多polinton编码可能的衣壳蛋白和病毒基因组包装ATP酶,与多种双链DNA (dsDNA)病毒相似。这支持了这样的推论:至少一些波林顿实际上是能够在细胞间传播的病毒。目前,公共序列数据库中还没有注释与波林顿相关的衣壳蛋白基因。为了弥补这一缺陷,我们使用数据挖掘方法来研究动物基因组和宏基因组序列数据集中的波林顿样元件和相关DNA病毒的分布和基因内容。结果定义了一个离散的类似病毒家族的进化枝,具有两个属级的划分。我们建议将其命名为腺病毒科(Adintoviridae),意味着与腺病毒病毒颗粒蛋白相似并且存在类似逆转录病毒的整合酶基因。尽管在真菌和各种单细胞真核生物的数据集中检测到了腺病毒类 PolB 序列,但类似于腺病毒病毒体蛋白和辅助基因的序列似乎仅限于动物。降解的腺病毒序列内源化到包括人类在内的多种动物的种系中。
更新日期:2020-10-02
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