Neuropathic pain (NP) is a multifaceted and ubiquitous disease across the globe. Mood disorders, such as anxiety and depression, are frequently observed in patients suffering from NP. Both NP and comorbid mood disorders seriously impacts the quality of life. Accumulated evidence shows that activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the neuroinflammatory pathogenesis of NP, anxiety, and depression. However, the role of the NLRP3 inflammasome in the pathological process of anxiety and depression under the NP state has not been fully described. Albiflorin (AF), a monoterpene glycoside, may be a potential regulator of the NLRP3 inflammasome, but it is not clear whether AF relates to NLRP3 inflammasome activation.

中文翻译：

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Albiflorin 通过抑制慢性收缩损伤期间海马 NLRP3 炎症小体的激活来减轻神经性疼痛状态下的情绪障碍

神经性疼痛 (NP) 是一种在全球范围内普遍存在的多方面疾病。在患有 NP 的患者中经常观察到情绪障碍，例如焦虑和抑郁。NP 和合并情绪障碍都会严重影响生活质量。积累的证据表明，NOD 样受体蛋白 3 (NLRP3) 炎症小体的激活与 NP、焦虑和抑郁的神经炎症发病机制有关。然而，NLRP3炎症小体在NP状态下焦虑和抑郁病理过程中的作用尚未得到充分描述。Albiflorin (AF) 是一种单萜糖苷，可能是 NLRP3 炎性体的潜在调节剂，但尚不清楚 AF 是否与 NLRP3 炎性体激活有关。