Background: Lifestyle genomics (LGx) is a science that explores interactions between genetic variation, lifestyle components such as physical activity (PA), and subsequent health- and performance-related outcomes. The objective of this study was to determine whether an LGx intervention could motivate enhanced engagement in PA to a greater extent than a population-based intervention. Methods: In this pragmatic randomized controlled trial, participants received either the standard, population-based Group Lifestyle BalanceTM (GLB) program intervention or the GLB program in addition to the provision of LGx information and advice (GLB + LGx). Participants (n = 140) completed a 7-day PA recall at baseline, 3, 6, and 12 months. Data from the PA recalls were used to calculate metabolic equivalents (METs), a measure of energy expenditure. Statistical analyses included split plot analyses of covariance and binary logistic regression (generalized linear models). Differences in leisure time PA weekly METs, weekly minutes of moderate + high-intensity PA, and adherence to PA guidelines were compared between groups (GLB and GLB + LGx) across the 4 time points. Results: Weekly METs were significantly higher in the GLB + LGx group (1,114.7 ± 141.9; 95% CI 831.5–1,397.8) compared to the standard GLB group (621.6 ± 141.9 MET/week; 95% CI 338.4–904.8) at the 6-month follow-up (p = 0.01). All other results were non-significant. Conclusions: The provision of an LGx intervention resulted in a greater weekly leisure time PA energy expenditure after the 6-month follow-up. Future research should determine how this could be sustained over the long-term. Clinical Trial Registration: NCT03015012.

中文翻译：

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与基于人群的干预相比，生活方式基因组学干预能否激励患者进行更多的体育锻炼？NOW 随机对照试验的结果

背景：生活方式基因组学 (LGx) 是一门探索遗传变异、生活方式组成部分（例如体育活动 (PA)）以及随后的健康和表现相关结果之间相互作用的科学。本研究的目的是确定 LGx 干预是否可以比基于人群的干预更大程度地促进 PA 的参与。方法：在这项务实的随机对照试验中，除了提供 LGx 信息和建议 (GLB + LGx) 之外，参与者还接受了标准的、基于人群的 Group Lifestyle BalanceTM (GLB) 计划干预或 GLB 计划。参与者 (n = 140) 在基线、3、6 和 12 个月时完成了 7 天的 PA 召回。来自 PA 召回的数据用于计算代谢当量 (MET)，这是一种能量消耗的衡量标准。统计分析包括协方差和二元逻辑回归（广义线性模型）的裂区分析。比较了 4 个时间点的各组（GLB 和 GLB + LGx）在闲暇时间 PA 每周 MET、每周中等强度 + 高强度 PA 分钟数以及对 PA 指南的遵守情况的差异。结果：与标准 GLB 组（621.6 ± 141.9 MET/周；95% CI 338.4–904）相比，GLB + LGx 组的每周 MET 显着更高（1,114.7 ± 141.9；95% CI 831.5–1,397.8）。月随访（p = 0.01）。所有其他结果都不显着。结论：在 6 个月的随访后，提供 LGx 干预导致每周休闲时间 PA 能量消耗增加。未来的研究应该确定如何长期维持这一点。临床试验注册：NCT03015012。