Abstract In the present study, a convenient and highly effective method was developed for the quantification of acidic drugs in wastewater and river water samples. Ultrasonic-assisted magnetic solid phase extraction employing magnetic waste tyre-based activated carbon nanocomposite functionalized with [3-(2-aminoethylamino)propyl]trimethoxysilane as a cost-effective and efficient adsorbent was used for the extraction and preconcentration of acidic drugs (naproxen [NAP], ketoprofen (KET) and diclofenac [DIC]). The quantification of target analytes was achieved by high‐performance liquid chromatography with diode array detector. Under optimum conditions, the detection limit, quantification limit and relative standard deviation obtained for the analytes of interest ranged from 0.38 to 0.76, 1.26 to 2.54 µg L−1 and 2.02 to 4.06%, respectively. The applicability of the developed method was assessed by the spike recovery tests and the relative recoveries proved that the method is reliable for the determination of acidic drugs in wastewater. Thereafter, the method was applied successfully for the determination of NAP, KET and DIC in river water, influent and effluent wastewater.

中文翻译：

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胺官能化磁性活性炭作为吸附剂，用于使用 HPLC-DAD 预浓缩和测定环境水样中的酸性药物

摘要 在本研究中，开发了一种简便高效的方法来定量废水和河水样品中的酸性药物。超声辅助磁固相萃取采用[3-(2-氨基乙基氨基)丙基]三甲氧基硅烷功能化的磁性废轮胎基活性炭纳米复合材料作为经济高效的吸附剂，用于酸性药物(萘普生[1])的提取和预浓缩。 NAP]、酮洛芬 (KET) 和双氯芬酸 [DIC])。目标分析物的定量是通过带二极管阵列检测器的高效液相色谱法实现的。在最佳条件下，目标分析物的检测限、定量限和相对标准偏差范围分别为 0.38 至 0.76、1.26 至 2.54 µg L-1 和 2.02 至 4.06%。通过加标回收率测试评估了所开发方法的适用性，相对回收率证明该方法对于废水中酸性药物的测定是可靠的。此后，该方法成功应用于河水、进出水废水中NAP、KET和DIC的测定。