Abstract

ZnFe₂O₄ nano-catalyzed facile synthesis of tetrahydropyranoquinoline derivatives (4a–f) via one-pot multi-component Povarov’s inverse-electron-demand hetero Diels–Alder reaction of substituted aromatic aldehyde (1), aromatic amine (2) with dihydrofuran (3) under ultrasonic irradiation. This may be helpful to society to get more active pharmaceutical ingredients. In the present study, a series of tetrahydroquinoline (4a–f) were synthesized and confirmed with several spectral characterization techniques. Synthetic approach of present research toward the synthesis of THQ was significantly shown that ZnFe₂O₄ plays a vital role in highly efficient, eco-friendly, recyclable heterogeneous nano-catalysts. This resulted in enhancing reaction rate, solvent-free reaction, easy to carry, simple isolation, and high yielded product.

摘要

ZnFe ₂ O ₄纳米催化通过取代芳香醛 (1)、芳香胺 (2) 与二氢呋喃的一锅多组分 Povarov 的反电子需求异质 Diels-Alder 反应轻松合成四氢吡喃喹啉衍生物 ( 4a-f ) (3)在超声波照射下。这可能有助于社会获得更多活性药物成分。在本研究中，合成了一系列四氢喹啉 ( 4a-f )，并通过多种光谱表征技术进行了确认。目前研究合成THQ的合成方法显着表明，ZnFe ₂ O ₄在高效、环保、可回收的多相纳米催化剂中发挥着至关重要的作用。从而提高了反应速率，反应无溶剂，携带方便，分离简单，产品收率高。