Since the first optogenetics study was published in 2005, its use in probing the link between neural circuits and behavior has increased exponentially. Recently, Gong et al. (Neuron 107:38-51,2020) developed an ultra-sensitive step-function opsin (SOUL) capable of activating any region of the mouse brain and cortical areas in macaques with external illumination, thus, aiming towards minimally-invasive light delivery. In this article, we highlight and discuss the new opsin's potential in non-human primate (NHP) research.

中文翻译：

---

具有新型超灵敏阶跃函数视蛋白 (SOUL) 的微创神经刺激：意义和未来方向

自 2005 年发表第一项光遗传学研究以来，它在探索神经回路与行为之间的联系方面的应用呈指数增长。最近，龚等人。(Neuron 107:38-51,2020) 开发了一种超灵敏的阶梯函数视蛋白 (SOUL)，能够在外部照明下激活小鼠大脑和皮层区域的任何区域，从而实现微创光传递。在本文中，我们重点介绍并讨论了新视蛋白在非人类灵长类动物 (NHP) 研究中的潜力。