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Mechanisms of epitranscriptomic gene regulation
Biopolymers ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1002/bip.23403
Kyung W Seo 1 , Ralph E Kleiner 1
Affiliation  

Chemical modifications on RNA can regulate fundamental biological processes. Recent efforts have illuminated the chemical diversity of posttranscriptional (“epitranscriptomic”) modifications on eukaryotic messenger RNA and have begun to elucidate their biological roles. In this review, we discuss our current molecular understanding of epitranscriptomic RNA modifications and their effects on gene expression. In particular, we highlight the role of modifications in mediating RNA‐protein interactions, RNA structure, and RNA‐RNA base pairing, and how these macromolecular interactions control biological processes in the cell.

中文翻译:

表观转录组基因调控机制

RNA 上的化学修饰可以调节基本的生物过程。最近的努力阐明了真核信使 RNA 转录后(“表转录组学”)修饰的化学多样性,并开始阐明它们的生物学作用。在这篇综述中,我们讨论了我们目前对表观转录组 RNA 修饰及其对基因表达影响的分子理解。我们特别强调了修饰在介导 RNA-蛋白质相互作用、RNA 结构和 RNA-RNA 碱基配对中的作用,以及这些大分子相互作用如何控制细胞中的生物过程。
更新日期:2020-10-01
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