The need to intensify downstream processing of monoclonal antibodies to complement the advances in upstream productivity has led to increased attention toward implementing membrane technologies. With the industry moving toward continuous operations and single use processes, membrane technologies show promise in fulfilling the industry needs due to their operational flexibility and ease of implementation. Recently, the applicability of membrane‐based unit operations in integrating the downstream process has been explored. In this article, the major developments in the application of membrane‐based technologies in the bioprocessing of monoclonal antibodies are reviewed. The recent progress toward developing intensified end‐to‐end bioprocesses and the critical role membrane technology will play in achieving this goal are focused upon.

中文翻译：

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利用膜技术强化下游对单克隆抗体的加工

加强单克隆抗体的下游加工以补充上游生产力的进步的需求已引起人们对实施膜技术的更多关注。随着行业朝着连续操作和一次性过程的方向发展，膜技术因其操作灵活性和易于实施而显示出满足行业需求的希望。最近，已经探索了基于膜的单元操作在整合下游过程中的适用性。本文概述了基于膜的技术在单克隆抗体生物处理中的应用进展。我们着重研究了开发端到端生物工艺的最新进展以及膜技术在实现这一目标中所起的关键作用。