How do four-legged animals adapt their locomotion to the environment? How do central and peripheral mechanisms interact within the spinal cord to produce adaptive locomotion and how is locomotion recovered when spinal circuits are perturbed? Salamanders are the only tetrapods that regenerate voluntary locomotion after full spinal transection. Given their evolutionary position, they provide a unique opportunity to bridge discoveries made in fish and mammalian models. Genetic dissection of salamander neural circuits is becoming feasible with new methods for precise manipulation, elimination, and visualisation of cells. These approaches can be combined with classical tools in neuroscience and with modelling and a robotic environment. We propose that salamanders provide a blueprint of the function, evolution, and regeneration of tetrapod locomotor circuits.

中文翻译：

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与蝾螈同行：从分子到生物机器人

四足动物如何使它们的运动适应环境？脊髓内的中枢和外周机制如何相互作用以产生适应性运动，以及当脊髓回路受到干扰时如何恢复运动？蝾螈是唯一一种在完全横断脊柱后再生自主运动的四足动物。鉴于它们的进化地位，它们提供了一个独特的机会来连接鱼类和哺乳动物模型中的发现。随着精确操作、消除和细胞可视化的新方法，蝾螈神经回路的遗传解剖变得可行。这些方法可以与神经科学中的经典工具以及建模和机器人环境相结合。我们建议蝾螈提供了功能、进化、