Calorie restriction is known to promote healthy aging, which includes prevention of muscle loss. We investigated the effect of rodent calorie restriction on mitochondrial respiration and clonogenic capacity of muscle satellite stem cells, since metabolic alterations are known to regulate stem cell activity. Surprisingly, short or long-term calorie restriction do not change mitochondrial or glycolytic function. Nevertheless, both short- and long-term calorie restriction enhance myogenic colony formation. Overall, our results show that not all changes in satellite stem cell function are accompanied by metabolic remodeling.

中文翻译：

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卡路里限制以一种独立于代谢调节的方式改变肌肉卫星细胞的增殖

众所周知，热量限制可以促进健康衰老，包括防止肌肉流失。我们研究了啮齿动物热量限制对线粒体呼吸和肌肉卫星干细胞克隆能力的影响，因为已知代谢改变可调节干细胞活性。令人惊讶的是，短期或长期热量限制不会改变线粒体或糖酵解功能。然而，短期和长期的卡路里限制都会增强生肌集落的形成。总的来说，我们的结果表明，并非卫星干细胞功能的所有变化都伴随着代谢重塑。