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Disconnection somewhere down the line: Multivariate lesion-symptom mapping of the line bisection error
Cortex ( IF 3.6 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.cortex.2020.09.012
Daniel Wiesen 1 , Hans-Otto Karnath 2 , Christoph Sperber 1
Affiliation  

Line Bisection is a simple task frequently used in stroke patients to diagnose disorders of spatial perception characterized by a directional bisection bias to the ipsilesional side. However, previous anatomical and behavioural findings are contradictory, and the diagnostic validity of the line bisection task has been challenged. We hereby aimed to re-analyse the anatomical basis of pathological line bisection by using multivariate lesion-symptom mapping and disconnection-symptom mapping based on support vector regression in a sample of 163 right hemispheric acute stroke patients. In line with some previous studies, we observed that pathological line bisection was related to more than a single focal lesion location. Cortical damage primarily to right parietal areas, particularly the inferior parietal lobe, including the angular gyrus, as well as damage to the right basal ganglia contributed to the pathology. In contrast to some previous studies, an involvement of frontal cortical brain areas in the line bisection task was not observed. Subcortically, damage to the right superior longitudinal fasciculus (I, II and III) and arcuate fasciculus as well as the internal capsule was associated with line bisection errors. Moreover, white matter damage of interhemispheric fibre bundles, such as the anterior commissure and posterior parts of the corpus callosum projecting into the left hemisphere, was predictive of pathological deviation in the line bisection task.



中文翻译:

线下某处的断开连接:线二等分误差的多处病变-症状映射

线平分法是一项简单的任务,经常用于中风患者,以诊断空间知觉障碍为特征的定向平分法偏向同侧。但是,先前的解剖学和行为学发现是矛盾的,并且线平分任务的诊断有效性受到了挑战。我们在此旨在通过对163例右半球急性中风患者的样本,基于支持向量回归,使用多元病变-症状映射和断开-症状映射,重新分析病理学线平分的解剖学基础。与之前的一些研究一致,我们观察到病理性线对分与不仅仅是单个病灶位置有关。皮质损害主要发生在右侧顶叶区域,尤其是顶下叶,包括角回,以及对右基底神经节的损害也是造成这种病理的原因。与以前的一些研究相比,未观察到额叶皮层大脑区域参与线平分任务。皮质下,右侧上纵筋膜(I,II和III)和弓形筋膜以及内囊的损害与线平分误差相关。此外,半球间纤维束的白质损伤,例如call体的前连合和后部伸入左半球,可预示线平分任务中的病理偏离。右上纵筋膜(I,II和III)和弓形筋膜以及内囊的损伤与线平分误差有关。此外,半球间纤维束的白质损伤,例如call体的前连合和后部伸入左半球,可预示线平分任务中的病理偏离。右上纵筋膜(I,II和III)和弓形筋膜以及内囊的损伤与线平分误差有关。此外,半球间纤维束的白质损伤,例如call体的前连合和后部伸入左半球,可预示线平分任务中的病理偏离。

更新日期:2020-10-30
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