Chlorogenic acid (CGA) is a strong phenolic antioxidant with antibacterial properties composed by a caffeoyl ester of quinic acid. Although a number of benefits has been reported and related to interactions with the red blood cell membranes, details on its membrane action and how composition and membrane state may affect it, is not yet well defined.

In this work, the interaction of CGA with lipid monolayers and bilayers composed by 1,2-dimiristoyl-sn-glycero-3-phosphocholine (DMPC); 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (14:0 diether PC); 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine (16:0 diether PC) were studied at different surface pressures (π). The kinetics of interaction was found to be more rapid in DMPC than in the absence of carbonyl groups. Measurements by FTIR-ATR at different water activities confirm specific interactions of CGA with carbonyl and phosphate groups affecting water level along hydrocarbon region.

The antioxidant activity of CGA in the presence of DMPC unilamellar vesicles, evidenced by the absorbance reduction of the radical cation ABTS^•+, is significantly different with respect to aqueous solution. The influence of CGA on antiradical activity (ARA) with lipid membranes depending on the hydration state of the lipid interface is discussed.

绿原酸（CGA）是一种强酚醛抗氧化剂，具有抗菌性能，由奎宁酸的咖啡酰酯组成。尽管已经报道了许多好处，并且与红细胞膜的相互作用有关，但是关于其膜作用以及组成和膜状态如何影响它的细节尚不清楚。

在这项工作中，CGA与由1,2-二亚氨基丙基-sn-甘油-3-磷酸胆碱（DMPC）组成的脂质单层和双层的相互作用；1,2-二- ö -tetradecyl- SN -glycero -3-磷酸胆碱（14：0二醚PC）; 在不同的表面压力（π）下研究了1,2-二棕榈酰-sn-甘油-3-磷酸胆碱（DPPC）和1,2-二-邻-十六烷基-sn-甘油-3-磷酸胆碱（16：0 diether PC） 。发现在DMPC中相互作用的动力学比在没有羰基的情况下更快。FTIR-ATR在不同水分活度下的测量结果证实了CGA与羰基和磷酸盐基团的特定相互作用会影响沿烃区域的水位。

DMPC单层囊泡存在下CGA的抗氧化活性，相对于水溶液而言，由自由基阳离子ABTS ^•+的吸光度降低所证明。讨论了CGA对脂质膜抗自由基活性（ARA）的影响，这取决于脂质界面的水合状态。